Structural basis of RNA-guided transcription by a dCas12f–σ<sup>E</sup>–RNAP complex

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First, we want to acknowledge how much this project depends on the broader neuroscience community. Our work builds directly on the adult fly connectome (Dorkenwald et al., 2024), on connectome-constrained brain models (Lappalainen et al., 2024), on neuromechanical fly body models (Wang-Chen et al., 2024; Ozdil et al., 2024), and on decades of work mapping sensory circuits, descending neurons, and behavior in Drosophila. The current system is an integration effort, most specifically of existing brain models and existing virtual body models. We’d also like to state that this work was a true team effort conducted by Scott Harris, Aarav Sinha, Viktor Toth, Alexis Pomares, and Philip Shiu.

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